Cymbalta treats depression, anxiety, and several chronic pain conditions. Learn how this medication works and what it’s prescribed for. Cymbalta is FDA-approved for major depressive disorder (MDD) and generalized anxiety disorder (GAD), but it is also approved for three pain conditions: diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Cymbalta is a prescription medicine used to treat symptoms of major depressive disorder, diabetic peripheral neuropathic pain, generalized anxiety disorder, fibromyalgia, and chronic muscle pain. Cymbalta (duloxetine) relieves pain by boosting two chemical messengers in your nervous system, serotonin and norepinephrine, that activate your body’s built-in pain suppression system. Cymbalta is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Cymbalta is used to treat generalized anxiety disorder and fibromyalgia in some children. The pediatric dose for these conditions is typically lower than the adult dose. Cymbalta is used to treat major depression, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain in adults, with some indications extending to children. Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Cymbalta (duloxetine) is a prescription drug for anxiety, pain from diabetic neuropathy, and other conditions. Learn about side effects, dosage, uses, and more. Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones.